人类遗传变异
进化生物学
生物
遗传变异
基因组
人类基因组
人口
遗传学
变化(天文学)
计算生物学
基因
人口学
社会学
天体物理学
物理
作者
Anders Bergström,Shane McCarthy,Ruoyun Hui,Mohamed A. Almarri,Qasim Ayub,Petr Danecek,Yuan Chen,Sabine Felkel,Pille Hallast,Jack Kamm,Hélène Blanché,Jean‐François Deleuze,Howard M. Cann,Swapan Mallick,David Reich,Manjinder S. Sandhu,Pontus Skoglund,Aylwyn Scally,Yali Xue,Richard Durbin
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2020-03-19
卷期号:367 (6484)
被引量:1046
标识
DOI:10.1126/science.aay5012
摘要
Genome sequences from diverse human groups are needed to understand the structure of genetic variation in our species and the history of, and relationships between, different populations. We present 929 high-coverage genome sequences from 54 diverse human populations, 26 of which are physically phased using linked-read sequencing. Analyses of these genomes reveal an excess of previously undocumented common genetic variation private to southern Africa, central Africa, Oceania, and the Americas, but an absence of such variants fixed between major geographical regions. We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and agriculturalist groups in the past 10,000 years, and a contrast between single Neanderthal but multiple Denisovan source populations contributing to present-day human populations.
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