Selenium Nanoparticles Enhance NK Cell‐Mediated Tumoricidal Activity in Malignant Pleural Effusion via the TrxR1‐IL‐18RAP‐pSTAT3 Pathway (Adv. Funct. Mater. 30/2024)

NK Cell-Mediated Tumoricidal Activity In article number 2401264, Tianfeng Chen, Jun Liu, Jinlin Wang, and co-workers address the problem that the immunosuppression of NK cells and selenium deficiency in TIME are treatment bottlenecks. The synergistic application of translational selenium nanoparticles serve to replenish selenium levels in MPE. Additionally, translational selenium nanoparticles facilitate NK cell activation through the TrxR1-IL18RAP-pSTAT3 pathway, resulting in effective elimination of lung cancer cells and reduction of pleural effusion.