脂质体
免疫疗法
光热治疗
结直肠癌
CD8型
癌症研究
癌症
黑磷
癌症疫苗
医学
材料科学
免疫系统
免疫学
纳米技术
内科学
光电子学
作者
Jinxie Zhang,Xiuli Chen,Tianyuan Xue,Qinzhen Cheng,Xinyu Ye,Changshan Wang,Yongkang Yu,Xiaoyuan Ji,Meiying Wu,Xudong Zhang,Yi Zheng,Ben-Qing Wu,Xin Liang,Lin Mei
标识
DOI:10.1166/jbn.2020.2977
摘要
Colorectal cancer frustrates with high relapse after the traditional treatment including surgery and chemotherapy. Neoantigen-based therapeutic vaccine has achieved high response rate in the clinical trials rising the immunotherapy as a promising alternative for colorectal cancer. Herein, colon cancer cells derived neoantigen peptide Adpgk were employed to be co-encapsulated with black phosphorus quantum dots into liposome (Adpgk-BPQDs-liposome) as therapeutic vaccine. Adpgk-BPQDs-liposome were dispersed in F127 gel containing GM-CSF. The heat generated by black phosphorus (BP) under 808 nm near-infrared laser irradiation accelerates the F127 gel ablation and the release of GM-CSF, which recruit APC cells and prime the native T cells. The tumor bearing mice received the programmed cell death protein 1 (PD-1) checkpoint blockade antibody combined with photo-thermal gel intensively prevented the tumor progress. Furthermore, the tumor infiltrating CD8+ T cells were significantly increased which lead to the elimination of the tumor.
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