抗菌剂
金黄色葡萄球菌
细菌
抗生素
肽
微生物学
抗生素耐药性
革兰氏阳性菌
革兰氏阴性菌
材料科学
大肠杆菌
生物
生物化学
遗传学
基因
作者
Wenyi Li,S Hadjigol,Alicia Rasines Mazo,James E. Holden,Jason C Lenzo,Steven J. Shirbin,Anders J. Barlow,Sadegh Shabani,Tao Huang,Eric C. Reynolds,Guanjun Qiao,Neil M O'Brien-Simpson
标识
DOI:10.1021/acsami.1c23734
摘要
Antibiotic resistance in bacteria, especially Gram-positive bacteria like Staphylococcus aureus, is gaining considerable momentum worldwide and unless checked will pose a global health crisis. With few new antibiotics coming on the market, there is a need for novel antimicrobial materials that target and kill multi-drug-resistant (MDR) Gram-positive pathogens like methicillin-resistant Staphylococcus aureus (MRSA). In this study, using a novel mixed-bacteria antimicrobial assay, we show that the star-peptide polymers preferentially target and kill Gram-positive pathogens including MRSA. A major effect on the activity of the star-peptide polymer was structure, with an eight-armed structure inducing the greatest bactericidal activity. The different star-peptide polymer structures were found to induce different mechanisms of bacterial death both in vitro and in vivo. These results highlight the potential utility of peptide/polymers to fabricate materials for therapeutic development against MDR Gram-positive bacterial infections.
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