生物制药
核酸
商业化
生物过程
核糖核酸
下游加工
生物技术
生物
化学
计算生物学
生化工程
生物化学
业务
工程类
基因
古生物学
营销
作者
Amin Javidanbardan,Kevork Oliver Messerian,Andrew L. Zydney
标识
DOI:10.1016/j.tibtech.2023.11.016
摘要
Nucleic acid therapeutics have the potential to revolutionize the biopharmaceutical industry, providing highly effective vaccines and novel treatments for cancers and genetic disorders. The successful commercialization of these therapeutics will require development of manufacturing strategies specifically tailored to the purification of nucleic acids. Membrane technologies already play a critical role in the downstream processing of nucleic acid therapeutics, ranging from clarification to concentration to selective purification. This review provides an overview of how membrane systems are currently used for nucleic acid purification, while highlighting areas of future need and opportunity, including adoption of membranes in continuous bioprocessing.
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