S100A12 is not expressed in rodents: Transgenic mouse model is needed

I read with interest the article authored by Zhang et al. (2020) who examined the role of S100A12 in the pathogenesis of sepsis-induced ARDS (acute respiratory distress syndrome). They used wild-type (WT) mice to measure the expression of S100A12 after induction of sepsis in mice. Based on the fact that S100A12 is not present in the murine genome, the interpretation of the findings could be misleading. Therefore, I discuss the use of S100A12 transgenic mouse models to examine S100A12 expression in mice.