生物材料
聚磷酸盐
溶菌酶
涂层
生物相容性
粘附
基质(水族馆)
材料科学
表面改性
纳米技术
钛
化学工程
化学
复合材料
生物化学
磷酸盐
生物
冶金
工程类
生态学
作者
Xinyuan Xu,Dongyue Zhang,Shangwei Gao,Toshikazu Shiba,Quan Yuan,Kai Cheng,Hong Tan,Jianshu Li
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2018-02-12
卷期号:19 (6): 1979-1989
被引量:18
标识
DOI:10.1021/acs.biomac.8b00002
摘要
Current implant materials have widespread clinical applications together with some disadvantages, the majority of which are the ease with which infections are induced and difficulty in exhibiting biocompatibility. For the efficient improvement of their properties, the development of interface multifunctional modification in a simple, universal, and environmently benign approach becomes a critical challenge and has acquired the attention of numerous scientists. In this study, a lysozyme-polyphosphate composite coating was fabricated for titanium(Ti)-based biomaterial to obtain a multifunctional surface. This coating was easily formed by sequentially soaking the substrate in reduced-lysozyme and polyphosphate solution. Such a composite coating has shown predominant antibacterial activity against Gram-negative bacteria (E. coli) and improved cell adhesion, proliferation, and differentiation, which are much better than those of the pure substrate. This facile modification endows the biomaterial with anti-infective and potential bone-regenerative performance for clinical applications of biomaterial implants.
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