聚乙烯亚胺
小干扰RNA
纳米技术
核糖核酸
纳米颗粒
聚合物
树枝状大分子
化学
材料科学
转染
生物化学
有机化学
基因
作者
Kaushik Singha,Ran Namgung,Won Jong Kim
出处
期刊:Nucleic Acid Therapeutics
[Mary Ann Liebert]
日期:2011-06-01
卷期号:21 (3): 133-147
被引量:174
标识
DOI:10.1089/nat.2011.0293
摘要
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.
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