医学
急性胰腺炎
肠外营养
相对风险
内科学
胰腺炎
肠内给药
置信区间
胃肠病学
荟萃分析
作者
Ping Feng,Chenjian He,Liao Guqing,Yanming Chen
出处
期刊:Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2017-11-01
卷期号:96 (46): e8648-e8648
被引量:34
标识
DOI:10.1097/md.0000000000008648
摘要
Background: Whether early enteral nutrition (EEN) administration is more beneficial than delayed enteral nutrition (DEN) for patients with acute pancreatitis remains controversial. Methods: This meta-analysis aimed to pool all relevant articles to evaluate the effects of EEN within 48 hours versus DEN beyond 48 hours on the clinical outcomes of patients with acute pancreatitis. We searched PubMed, Scopus, Embase, and Web of Science for all relevant studies and extracted the data concerning basic characteristics, complications, and mortality. We calculated the pooled risk ratio (RR), weighted mean difference, and the corresponding 95% confidential interval (95% CI) using STATA 12.0. Results: For complications, the pooled analysis showed that EEN was related to a reduced risk of multiple organ failure (RR = 0.67, 95% CI 0.46–0.99, P = .04), but not for necrotizing pancreatitis (RR = 0.95, 95% CI 0.81–1.12, P = .57). There was a tendency for decreased systemic inflammatory response syndrome in the EEN group, but the trend was not significant (RR = 0.85, 95% CI 0.71–1.02, P = .09). For mortality, no significant difference was found between the EEN and DEN groups (RR = 0.78, 95% CI 0.27–2.24, P = .64). Conclusion: EEN within 48 hours is superior to DEN beyond 48 hours for patients with acute pancreatitis; however, more studies are required to verify this conclusion.
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