白蛋白
体内
对比度(视觉)
荧光素
计算机科学
班级(哲学)
药代动力学
DNA
计算生物学
化学
人工智能
生物化学
生物信息学
光学
生物
荧光
物理
遗传学
作者
Christoph E. Dumelin,Sabrina Trüssel,Fabian Buller,Eveline Trachsel,Frank Bootz,Yixin Zhang,Luca Mannocci,Susanne Beck,Mihaela Drumea-Mirancea,Mathias W. Seeliger,Christof Baltes,Thomas Müggler,Felicitas Kranz,Markus Rudin,Samu Melkko,Jörg Scheuermann,Dario Neri
标识
DOI:10.1002/anie.200704936
摘要
Seeing eye to eye: Plasma-protein binding is effective in improving the pharmacokinetic properties of otherwise short-lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half-life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704936_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
科研通智能强力驱动
Strongly Powered by AbleSci AI