化学
机制(生物学)
群(周期表)
生物合成
组合化学
生物化学
有机化学
认识论
基因
哲学
作者
Tzu‐Yu Chen,Jinfeng Chen,Yijie Tang,Jiahai Zhou,Yisong Guo,Wei‐chen Chang
标识
DOI:10.1002/cjoc.202000448
摘要
Isonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation. Based on the strategies utilized, two fundamentally distinctive approaches are discussed. In addition, recent progress in elucidating isonitrile group formation mechanisms is also presented.
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