姜黄素
荧光
体内
共轭体系
离域电子
化学
荧光互相关光谱
生物物理学
荧光寿命成像显微镜
光化学
分子
生命科学中的荧光
激光诱导荧光
生物化学
有机化学
聚合物
光学
生物
物理
生物技术
作者
Yu Liu,Chuang Zhang,Hao Pan,Li Li,Yanjie Yu,Bing-Mi Liu
标识
DOI:10.1016/j.ajps.2020.11.003
摘要
Curcumin and its derivatives have good electrical and optical properties due to the highly symmetric structure of delocalized π electrons. Apart from that, curcumin and its derivatives can interact with numerous molecular targets, thereby exerting less side effects on human body. The fluorescence emission wavelength and fluorescence intensity of curcumin can be enhanced by modifying its π-conjugated system and ß-diketone structure. Some curcumin-based fluorescent probes have been utilized to detect soluble/insoluble amyloid-ß protein, intracranial reactive oxygen species, cysteine, cancer cells, etc. Based on the binding characteristics of curcumin-based fluorescent probes with various target molecules, the factors affecting the fluorescence intensity and emission wavelength of the probes are analyzed, in order to obtain a curcumin probe with higher sensitivity and selectivity. Such an approach will be greatly applicable to in vivo fluorescence imaging.
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