雷达51
生物
同源重组
基因组不稳定性
遗传学
DNA修复
范科尼贫血
生殖系
DNA损伤
基因组
DNA复制
计算生物学
基因
DNA
作者
Debanjali Bhattacharya,Satyaranjan Sahoo,Tarun Nagraj,Suruchi Dixit,Harsh Kumar Dwivedi,Ganesh Nagaraju
标识
DOI:10.1016/j.coph.2022.102313
摘要
Mammalian RAD51 paralogs are essential for cell survival and are critical for RAD51-mediated repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). However, the molecular mechanism by which RAD51 paralogs participate in HR is largely unclear. Germline mutations in RAD51 paralogs are associated with breast and ovarian cancers and Fanconi anemia-like disorder, underscoring the crucial roles of RAD51 paralogs in genome maintenance and tumor suppression. Despite their discovery over three decades ago, the essential functions of RAD51 paralogs in cell survival and genome stability remain obscure. Recent studies unravel DSB repair independent functions of RAD51 paralogs in replication stress responses. Here, we highlight the recent findings that uncovered the novel functions of RAD51 paralogs in replication fork progression, its stability, and restart and discuss RAD51 paralogs as a potential therapeutic target for cancer treatment.
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