Substrate‐Dependent Divergent Oxyamination of beta‐Tetralones Enabling Modular Synthesis of 2‐Amino‐para‐Iminonaphthoquinones and 4‐Amino‐1,2‐Naphthoquinone Derivatives

Abstract A regioselective synthesis of 2‐amino‐ para ‐iminonaphthoquinones and 4‐amino‐1,2‐naphthoquinones was described via the substrate‐dependent divergent multi‐functionalization of β ‐tetralone with primary and secondary amines under metal‐free conditions. This developed strategy features extremely green and mild conditions (O 2 as oxidant, ethanol as solvent under ambient temperature), broad substrate scope, and various pharmaceutical derivatizations. magnified image