代谢工程
萜类
合成生物学
生化工程
生物技术
生物
化学
计算生物学
工程类
生物化学
基因
作者
Yatian Cheng,Hao Tang,Lili Sun,Ying Hu,Ying Ma,Juan Guo,Luqi Huang
出处
期刊:PubMed
日期:2023-06-25
卷期号:39 (6): 2265-2283
标识
DOI:10.13345/j.cjb.230063
摘要
Natural plant-derived diterpenoids are a class of compounds with diverse structures and functions. These compounds are widely used in pharmaceuticals, cosmetics and food additives industries because of their pharmacological properties such as anticancer, anti-inflammatory and antibacterial activities. In recent years, with the gradual discovery of functional genes in the biosynthetic pathway of plant-derived diterpenoids and the development of synthetic biotechnology, great efforts have been made to construct a variety of diterpenoid microbial cell factories through metabolic engineering and synthetic biology, resulting in gram-level production of many compounds. This article summarizes the construction of plant-derived diterpenoid microbial cell factories through synthetic biotechnology, followed by introducing the metabolic engineering strategies applied to improve plant-derived diterpenoids production, with the aim to provide a reference for the construction of high-yield plant-derived diterpenoid microbial cell factories and the industrial production of diterpenoids.
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