Mucosal zipper endoscopic resection offers a novel option for the treatment of gastric submucosal tumors

Endoscopic full-thickness resection (EFTR) has become the mainstream endoscopic resection method for gastric submucosal tumors (SMTs). EFTR enables access to deeper lesions by intentionally creating a full-thickness defect, as opposed to relying on accidental perforation [1] [2]. Consequently, closure of the iatrogenic defect remains one of the most critical technical challenges associated with EFTR. Most existing techniques involve full-thickness clamping of the gastric wall, which hinders the spontaneous detachment of metal clips. Additionally, these techniques often require specialized instruments and involve complex procedures, resulting in increased material consumption and costs, which limits their widespread clinical application [3] [4] [5].