单核吞噬细胞系统
钾通道
吞噬细胞
趋化性
小胶质细胞
海马结构
生物
单核细胞
免疫学
细胞生物学
神经科学
吞噬作用
炎症
内分泌学
生物化学
受体
作者
In Kwon Chung,Marina Zelivyanskaya,Howard E. Gendelman
标识
DOI:10.1016/s0165-5728(01)00462-3
摘要
Mononuclear phagocyte (MP) brain migration influence neuronal damage during HIV-1-associated dementia (HAD). We demonstrate that potassium channels, expressed in human monocyte-derived macrophages (MDM), are vital for MP movement through Boyden chemotactic chambers, an artificial blood–brain barrier and organotypic hippocampal brain slices. MDM migration is inhibited by voltage-and calcium-activated potassium channel blockers that include charybodotoxin, margatoxin, agatoxin and apamin. This is observed both in uninfected and HIV-1-infected MP. The results suggest that potassium channels affect MDM brain migration through altering cell volume and shape. Such mechanisms likely affect MP-induced neuronal destruction during HAD.
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