鸟嘌呤
电极
循环伏安法
石墨烯
电化学
微分脉冲伏安法
化学
氧化物
伏安法
检出限
氧化还原
分析化学(期刊)
无机化学
材料科学
纳米技术
有机化学
色谱法
物理化学
生物化学
核苷酸
基因
作者
Juan Xu,Tianbao Li,Lingli Wang,Jian-Chun Wang,Lei Zhao,Shaofei Shen,Qin Tu,Yanrong Zhang,Jinyi Wang
出处
期刊:Journal of The Electrochemical Society
[The Electrochemical Society]
日期:2014-01-01
卷期号:161 (4): G21-G25
被引量:3
摘要
The electrochemically reduced graphene oxide modified glass carbon (ERGO/GC) electrode was prepared in situ from graphene oxide modified glass carbon (GO/GC) electrode. The electro-oxidation of guanine at the ERGO/GC electrode was investigated by cyclic voltammetry and differential pulse voltammetry under controlled pH and concentration conditions. The ERGO/GC electrode showed a significantly enhanced voltammetric response for guanine due to the increase of the electrochemical active surface area and the conductivity of the electrode during the reduction process. The electro-oxidation reaction of guanine was identified to involve two electrons and two protons. The voltammetric peak currents were linearly dependent on the concentration of guanine in the range of 0.5 to 10 μM. The voltammetric peaks in cell lysates were attributed to the oxidation of guanine in RNA and DNA of cells. The peak current was increased linearly with increase in the amount of cells with a detection limit of 1 × 105 cells mL−1 (S/N = 3).
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