废止
化学
哒嗪
立体化学
戒指(化学)
双键
对映体
立体选择性
组合化学
基质(水族馆)
功能群
有机化学
催化作用
海洋学
地质学
聚合物
作者
Man Zhu,Yuyao Zhao,Xingwei Li,Bingxian Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-03-13
卷期号:25 (11): 1839-1844
被引量:3
标识
DOI:10.1021/acs.orglett.3c00278
摘要
N-Heterocycle-assisted C-H activation/annulation reactions have provided new concepts for the construction and transformation of azacycles. In this work, we disclose a [5+1] annulation reaction using a novel transformable pyridazine directing group (DG). The DG-transformable reaction mode led to the construction of a new heterocyclic ring accompanied by transformation of the original pyridazine directing group via a C-H activation/1,4-Rh migration/double bond shift pathway, affording the skeleton of pyridazino[6,1-b]quinazolines with a good substrate scope under mild conditions. Diverse fused cyclic compounds can be achieved by derivatization of the product. The asymmetric synthesis of the skeleton was also realized to afford the enantiomeric products with good stereoselectivity.
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