In the present work, we have carried out a comprehensive electron interaction study with an important hydrofluorocarbon gas, difluoromethane (CH2F2), over a wide energy range (0.1–5000 eV). Various elastic and inelastic molecular processes are quantified and reported through differential and total cross sections. In order to investigate interactions for such a wide energy range, we have used ab initio R-matrix formalism for low energies and the Spherical Complex Optical Potential approach for intermediate- to high-energy regimes. We have evaluated the ionization cross sections using complex scattering potential-ionization contribution and Binary-Encounter-Bethe methods.