骨质疏松症
心理压力
压力(语言学)
医学
心理学
临床心理学
内科学
哲学
语言学
作者
Hao-Kun Xu,Jie-Xi Liu,Zhenlei Zhou,Chenxi Zheng,Bing‐Dong Sui,Yuan Yuan,Liang Kong,Yan Jin,Ji Chen
标识
DOI:10.1093/lifemedi/lnae009
摘要
Abstract Psychological stress has been associated with the onset of several diseases, including osteoporosis. However, the underlying pathogenic mechanism remains unknown, and effective therapeutic strategies are still unavailable. Growing evidence suggests that the sympathetic nervous system regulates bone homeostasis and vascular function under psychological stress, as well as the coupling of osteogenesis and angiogenesis in bone development, remodeling, and regeneration. Furthermore, extracellular vesicles (EVs), particularly mesenchymal stem cell extracellular vesicles (MSC–EVs), have emerged as prospecting therapies for stimulating angiogenesis and bone regeneration. We summarize the role of sympathetic regulation in bone homeostasis and vascular function in response to psychological stress and emphasize the relationship between vessels and bone. Finally, we suggest using MSC–EVs as a promising therapeutic method for treating osteoporosis in psychological stress.
科研通智能强力驱动
Strongly Powered by AbleSci AI