Invasive and pharmacological treatment of acute coronary syndrome

PART A ACS care in the Netherlands 23 Chapter 2 Impact of off-site percutaneous coronary intervention on accessibility to coronary revascularization in the Netherlands 25 Chapter 3 Practice of ST-segment elevation myocardial infarction care in the Netherlands during four snapshot weeks with the National Cardiovascular Database Registry for Acute Coronary Syndrome 41 Chapter 4 Treatment patterns of non-ST-elevation acute coronary syndrome patients presenting at non-PCI centres in the Netherlands and possible logistical consequences of adopting same-day transfer to PCI centres: a registrybased evaluation 57 PART B Long-term results of the ICTUS trial 75 Chapter 5 Early invasive versus selective strategy for non-ST-segment elevation acute coronary syndrome: the ICTUS trial 77 Chapter 6 Early revascularization in NSTE-ACS: insights from the ICTUS long-term follow-up 101 Chapter 7 Ten-year outcomes of an early invasive versus a selective invasive strategy in non-ST-segment elevation acute coronary syndrome patients with and without diabetes mellitus: a subgroup analysis of the ICTUS trial .107 Chapter PART C Pharmacological treatment of ACS patients 127 Chapter 8 Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a patientpooled meta-analysis of randomized clinical trials 129 Chapter 9 Trends in optimal medical therapy prescription and mortality after admission for acute coronary syndrome: a 9-year experience in a real-world setting 153 Chapter 10 Trends in cardiovascular and bleeding outcomes in acute coronary syndrome patients treated with or without proton-pump inhibitors during the introduction of novel P2Y12 inhibitors: a five-year experience from a singlecentre observational registry 179 Chapter 11 Optimal medical therapy prescription after acute coronary syndrome in the Netherlands: a multicentre pilot registry 205