持续气道正压
医学
阻塞性睡眠呼吸暂停
冲程(发动机)
随机对照试验
呼吸暂停
内科学
对数秩检验
麻醉
睡眠呼吸暂停
气道正压
生存分析
心脏病学
机械工程
工程类
作者
Olga Parra,Ángeles Sánchez‐Armengol,Francisco Capote,Mar Colorado Bonnin,Adrià Arboix,Francisco Campos‐Rodríguez,Jose Pérez-Ronchel,Joaquín Durán-Cantolla,Cristina Martínez-Null,Mónica de la Peña,Maria Carmen Jiménez,Fernando Masa,Ignacio Casadon,M.L. Alonso,José L. Macarrón
摘要
The main purpose of the present analysis is to assess the influence of introducing early nasal continuous positive airway pressure (nCPAP) treatment on cardiovascular recurrences and mortality in patients with a first-ever ischaemic stroke and moderate-severe obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) ≥20 events h(-1) during a 5-year follow-up. Patients received conventional treatment for stroke and were assigned randomly to the nCPAP group (n = 71) or the control group (n = 69). Cardiovascular events and mortality were registered for all patients. Survival and cardiovascular event-free survival analysis were performed after 5-year follow-up using the Kaplan-Meier test. Patients in the nCPAP group had significantly higher cardiovascular survival than the control group (100 versus 89.9%, log-rank test 5.887; P = 0.015) However, and also despite a positive tendency, there were no significant differences in the cardiovascular event-free survival at 68 months between the nCPAP and control groups (89.5 versus 75.4%, log-rank test 3.565; P = 0.059). Early nCPAP therapy has a positive effect on long-term survival in ischaemic stroke patients and moderate-severe OSA.
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