β‐Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in Macrophages

A chemical knockout of the virulence regulator ClpP by β-lactones in Listeria monocytogenes resulted in a reduced production of the major virulence factor listeriolysin O as well as of PI-phospholipase C. This led to a significant decrease in intracellular replication of the pathogen in mouse macrophage cells. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.