Chlorthalidone vs. Hydrochlorothiazide for Treatment of Hypertension.

Chlorthalidone produces slightly greater reductions in blood pressure compared with hydrochlorothiazide (HCTZ), but it is associated with greater declines in serum potassium levels. Chlorthalidone lowers the risk of cardiovascular events about 18% more than HCTZ at the same achieved blood pressure.