癌细胞
谷胱甘肽
阿霉素
细胞毒性
化学
药物输送
靶向给药
半胱氨酸
药品
生物物理学
癌症
生物化学
癌症研究
药理学
体外
化疗
医学
生物
酶
有机化学
外科
内科学
作者
Sonika Chibh,Avneet Kour,Nitin Yadav,Pankaj Kumar,Pratik Yadav,Virander S. Chauhan,Jiban Jyoti Panda
出处
期刊:ACS omega
[American Chemical Society]
日期:2020-02-11
卷期号:5 (7): 3365-3375
被引量:35
标识
DOI:10.1021/acsomega.9b03547
摘要
Materials that exhibit responsiveness toward biological signals are currently subjected to intense research in the field of drug delivery. In our study, we tried to develop cancer-targeted and redox-responsive nanoparticles (NPs) from disulfide-linked oxidized cysteine-phenylalanine (CFO). The NPs were conjugated with folic acid (FA) to specifically target cancer cells, and the presence of disulfide bonds would enabled the disintegration of the particles in the presence of elevated levels of glutathione (GSH) in cancer cells. Anticancer drug doxorubicin (Dox) was successfully loaded inside the disulfide-linked nanoparticles (CFO-Dox-NPs), which further demonstrated stimuli-responsive drug release in the presence of GSH. We have also demonstrated enhanced uptake of FA-derivatized NPs (FA-CFO-NPs) in cancerous cells (C6 glioma and B16F10 melanoma cells) than in normal cells (HEK293T cells) due to the overexpression of FA receptors on the surface of cancer cells. Cytotoxicity studies in C6 cells and B16F10 cells further revealed enhanced efficacy of Dox loaded (FA-CFO-Dox-NPs) as compared to the native drug. The findings of this study clearly demonstrated that the disulfide-linked nanoparticle system may provide a promising selective drug delivery platform in cancer cells.
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