Objective To explore the Fundus fluorescein angiography in the early diagnosis of diabetic retinopathy significance. Methods 300 cases(273 eyes) diabetic patients clinical data were collectes from 2010 December to 2012 December,and all patients were checked with ophthalmoscope and fundus fluorescein angiography two checking methods. Results 153 cases were checked by the ophthalmoscopic lesions number,lesions was 56.05%;251 cases were detected by FFA lesions,which followed by fundus fluorescein angiography,lesions was 91.94%.The diagnosis of fundus fluorescein angiography of the correct rate had a higher Correct rate,the difference was statistically significant between the two groups(P 0.05).Non proliferative diabetic retinopathy had 55 cases by FFA lesions,accounting for 21.91% disease variables;preproliferative diabetic retinopathy had 73 cases,accounting for 29.08%;proliferative diabetic retinopathy had 65 cases,accounting for 25.91%;diabetic macularlesions had 35 cases,accounting for 13.94%;diabetic papillopathy had 23 cases,accounting for 9.16%. Conclusion Early diabetic retinopathy fluorescein angiography can be found on thelens cannot make diagnosis.