Diffusion Tensor Imaging‐Along the Perivascular‐Space Index Is Associated with Disease Progression in Parkinson's Disease

磁共振弥散成像 帕金森病 认知功能衰退 认知 医学 淋巴系统 内科学 疾病 心理学 病理 物理医学与康复 神经科学 痴呆 磁共振成像 放射科 脑脊液
作者
Kimberly H. Wood,Rodolphe Nenert,Aya M. Miften,George W. Kent,Madison Sleyster,Raima Memon,Allen Joop,Jennifer Pilkington,Adeel Memon,Riis N. Wilson,Corina Catiul,Jerzy P. Szaflarski,Amy W. Amara
出处
期刊:Movement Disorders [Wiley]
卷期号:39 (9): 1504-1513 被引量:24
标识
DOI:10.1002/mds.29908
摘要

Abstract Background The glymphatic clearance pathway is a waste clearance system that allows for removal of soluble proteins such as amyloid β (Aβ) from the brain. Higher Aβ levels are associated with cognitive dysfunction in Parkinson's disease (PD). Diffusion tensor imaging‐along the perivascular space (DTI‐ALPS) is an imaging measure proposed to indirectly measure glymphatic function. Objectives Evaluate differences in DTI‐ALPS‐index between PD and healthy controls (HC) and characterize relationships between this proposed measure of glymphatic clearance, cognition, and disease severity in PD. Methods PD (n = 32) and HC (n = 23) participants underwent brain imaging to assess DTI‐ALPS. PD participants were classified as PD‐normal cognition (PD‐NC; n = 20) or PD‐mild cognitive impairment (PD‐MCI; n = 12) based on a Level II comprehensive cognitive assessment. A subgroup of PD participants (n = 21) returned for annual assessments for up to 4 years after baseline. Longitudinal outcomes included changes in performance on the comprehensive cognitive assessment and changes in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS). Results PD participants had lower DTI‐ALPS‐index compared to HC. PD participants classified as PD‐MCI had significantly lower DTI‐ALPS‐index compared to PD‐NC. Lower DTI‐ALPS‐index at baseline was associated with longitudinal cognitive decline and worse longitudinal disease severity. Conclusions Glymphatic clearance, as measured with DTI‐ALPS, has potential to serve as a marker of longitudinal disease progression. Interventions targeting glymphatic function should be explored for potential to slow cognitive decline in PD. © 2024 International Parkinson and Movement Disorder Society.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
南滨完成签到 ,获得积分10
1秒前
内向寒云完成签到,获得积分10
2秒前
2秒前
李健的小迷弟应助yomoo采纳,获得10
2秒前
Lucas应助旅途之人采纳,获得10
2秒前
mkb完成签到,获得积分10
3秒前
lee1992发布了新的文献求助10
3秒前
5秒前
7秒前
无私静白完成签到,获得积分10
7秒前
图图关注了科研通微信公众号
8秒前
神秘骑士发布了新的文献求助10
8秒前
漂亮的忆文完成签到,获得积分10
8秒前
9秒前
qmx发布了新的文献求助10
9秒前
过时的友卉完成签到,获得积分10
9秒前
饱满的百招完成签到 ,获得积分10
10秒前
完美世界应助yzbj采纳,获得10
10秒前
13秒前
风清扬应助研友_8o5V2n采纳,获得10
13秒前
14秒前
共享精神应助qmx采纳,获得10
14秒前
爱笑的万天完成签到,获得积分10
15秒前
RPG完成签到,获得积分10
15秒前
15秒前
16秒前
Wave浪发布了新的文献求助30
17秒前
仿真小学生完成签到,获得积分10
18秒前
昂口3完成签到 ,获得积分10
18秒前
缥缈芷珍发布了新的文献求助10
19秒前
vielate发布了新的文献求助10
19秒前
21秒前
23秒前
23秒前
yzbj完成签到,获得积分10
25秒前
鸣笛应助自然思松采纳,获得20
27秒前
罗罗发布了新的文献求助10
27秒前
大个应助怕黑的盼烟采纳,获得10
27秒前
jz完成签到,获得积分10
28秒前
万能图书馆应助宁缺毋滥采纳,获得10
30秒前
高分求助中
【重要!!请各位用户详细阅读此贴】科研通的精品贴汇总(请勿应助) 10000
Semantics for Latin: An Introduction 1055
Plutonium Handbook 1000
Three plays : drama 1000
Robot-supported joining of reinforcement textiles with one-sided sewing heads 600
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 510
Cochrane Handbook for Systematic Reviews ofInterventions(current version) 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4103626
求助须知:如何正确求助?哪些是违规求助? 3641325
关于积分的说明 11538745
捐赠科研通 3349911
什么是DOI,文献DOI怎么找? 1840560
邀请新用户注册赠送积分活动 907604
科研通“疑难数据库(出版商)”最低求助积分说明 824725