医学
乳腺癌
放射科
淋巴结
腋窝淋巴结清扫术
活检
哨兵节点
前哨淋巴结
腋窝
腋窝解剖
淋巴
解剖(医学)
癌症
核医学
内科学
病理
作者
Ece Dilege,Burak Çelik,Okan Falay,Medine Böge,Serkan Sucu,Safa Toprak,Orhan Ağcaoğlu,Nilgün Kapucuoğlu,Mehmet Onur Demirkol
出处
期刊:Clinical Nuclear Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2023-04-17
卷期号:48 (7): 594-599
被引量:2
标识
DOI:10.1097/rlu.0000000000004669
摘要
Purpose The aim of this study was to evaluate the impact of SPECT/CT lymphoscintigraphy on targeted axillary dissection (TAD) in node-positive breast cancer (BC) patients who had undergone neoadjuvant chemotherapy (NAC). Methods Sixty-two female BC patients with biopsy-confirmed axillary nodal metastases underwent NAC, followed by breast surgery with TAD. A metallic clip was placed in the sampled LN before NAC. On the day of surgery, a periareolar intradermal 99m Tc-nanocolloid injection was administered, followed by SPECT/CT lymphoscintigraphy. The clipped nodes were localized on CT images, assessed for 99m Tc uptake before surgery, and confirmed during the procedure. Results T1–4, N1–2 patients were enrolled in the study. All patients underwent sentinel lymph node (SLN) biopsy. The clipped node was the SLN in 54 (88.5%) patients. In 3 patients (4.9%), a clip was found in a nonsentinel lymph node. In 4 patients, the clips were not visible on SPECT/CT images, and lymph nodes were not found during the procedure. SPECT/CT correctly localized the clipped lymph node in all patients. The overall false-negative rate for TAD was 3.33%. The mean follow-up duration was 29 months, and there were no axillary recurrences. Conclusions SPECT/CT lymphoscintigraphy can accurately localize clipped nodes and SLNs after NAC in patients with node-positive BC.
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