5-羟色胺能
血清素
生物
神经科学
5-羟色胺受体
连接体
觅食
受体
功能连接
生态学
生物化学
作者
Uğur Dağ,Ijeoma Nwabudike,Di Kang,Matthew A Gomes,Jungsoo Kim,Adam A. Atanas,Eric Bueno,Cassi Estrem,Sarah Pugliese,Ziyu Wang,Emma K. Towlson,Steven W. Flavell
出处
期刊:Cell
[Elsevier]
日期:2023-06-01
卷期号:186 (12): 2574-2592.e20
被引量:4
标识
DOI:10.1016/j.cell.2023.04.023
摘要
Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse receptors across the brain to modulate global activity and behavior is unknown. Here, we examine how serotonin release in C. elegans alters brain-wide activity to induce foraging behaviors, like slow locomotion and increased feeding. Comprehensive genetic analyses identify three core serotonin receptors (MOD-1, SER-4, and LGC-50) that induce slow locomotion upon serotonin release and others (SER-1, SER-5, and SER-7) that interact with them to modulate this behavior. SER-4 induces behavioral responses to sudden increases in serotonin release, whereas MOD-1 induces responses to persistent release. Whole-brain imaging reveals widespread serotonin-associated brain dynamics, spanning many behavioral networks. We map all sites of serotonin receptor expression in the connectome, which, together with synaptic connectivity, helps predict which neurons show serotonin-associated activity. These results reveal how serotonin acts at defined sites across a connectome to modulate brain-wide activity and behavior.
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