Efficacy of autologous platelet-rich plasma combined with hyaluronic acid on skin facial rejuvenation: A prospective study

Corresponding medical records of included cases were then reviewed, with cases of icSCC treated via curettage alone included in this study.Patient and tumor characteristics were recorded, including duration of follow-up through the end of the study period (May 17, 2015).Tumors were considered recurrent if there was documentation of clinician or patient suspicion for recurrence with histologic confirmation of icSCC at the same site.Overall, 89 individual lesions from 80 unique patients met inclusion criteria and were included in this study.Duration of follow-up extended from 0 to 2502 days (6.8 years), with a median of 6 years.Most patients were male, with a mean age of 76 years at the time of diagnosis (Table I).Forty-four percent of lesions were located in low-risk sites, with a mean pretreatment size of 0.9 cm (range, 0.3-2.5 cm).Most lesions (76%) had tumor present at histologic margins, and 91% were well-differentiated (Table II).Three recurrences were identified (overall cure rate, 97%), 2 of which were located on high-risk sites, and 2 of the 3 recurrent lesions initially had positive histologic margins (Table II).One recurrent lesion was located on a high-risk site and was present at histologic margins before treatment with curettage.All recurrent lesions were welldifferentiated histologically (Table II).Time to recurrence (days) was 60, 68, and 78; 2 recurrences were initially curetted by the same staff dermatologist.Limitations of this study include incomplete medical records and suboptimal site documentation, potentially leading to missed recurrent tumors.Additionally, variation in curettage technique may have been present between clinicians (eg, disposable versus reusable curettes, number of passes with the curette) and practitioners may have preselected tumors and patients with certain characteristics for curettage alone.In conclusion, this study demonstrated a 97% cure rate of icSCC by curettage alone. 4 Providers with adequate training in this technique should consider this treatment in icSCC with comparable features because it can be an efficient and effective modality for treating this tumor.Our small sample size precludes strong recommendations for precise tumor or technique selection.A prospective study is needed to further explore risk factors for recurrence as well as cosmetic outcomes, healing time, and complications associated with this procedure.